Browse Items (14 total)

  • Collection: Copper-based Catalysts

Preparation of enynes via copper-catalyzed stereoselective cross-coupling of terminal alkynes with vinyl iodides.

A copper(I)-catalyzed procedure for the synthesis of 1,3-enynes, e.g., 99 % Et (Z)-5-phenyl-2-penten-4-ynoate from phenylacetylene and Et (Z)-3-iodoacrylate using 10 mol% [Cu(bipy)(PPh3)Br] and 2.0 equiv K2CO3 in toluene at 110° for 8 h, is…

Process for preparation of aryl thioethers and aryl selenoethers by copper(I) catalyzed coupling of thiols and selenols with aryl halides.

A mild, palladium-free improved process for prepn. of aryl thioethers and selenoethers comprise reaction of thiols and selenols with aryl halides, preferably aryl iodides catalyzed by copper(I) halide complexes with bidentate ligands, preferably…

Process for preparation of benzo[b]heterocycles from arylacetylenes and halophenols or haloanilines in the presence of copper(I) catalysts.

Benzo[b]heterocycles were prepd. by reaction of an arylacetylene with an o-halophenol or o-haloaniline in the presence of a bidentate Cu(I) catalyst. Thus, reaction of PhC≡CH with 2-IC6H4NH2 in the presence of [Cu(phen)(PPh3)]NO3 (prepn. given)…

Synthesis of diaryl ethers using an easy-to-prepare, air-stable, soluble copper(I) catalyst

We have found that bromo(triphenylphosphine)copper(I), an air-stable and soluble copper(I) complex, can be used as a catalyst in the synthesis of diaryl ethers. Using this catalyst, we have synthesized diaryl ethers from electron-rich aryl bromides…

Formation of aryl-nitrogen bonds using a soluble copper(I) catalyst

We report a synthetic protocol for the synthesis of functionalized diaryl- and triarylamines under mild conditions, using a soluble, air-stable copper(I) complex. Cu(PPh3)(3)Br, as the catalyst and cesium carbonate as the base. Using this protocol,…

Formation of aryl-nitrogen, aryl-oxygen, and aryl-carbon bonds using well-defined copper(I)-based catalysts

[GRAPHICS] We report mild synthetic protocols for the formation of aryl-carbon, aryl-nitrogen, and aryl-oxygen bonds based on soluble, well-defined copper(I) catalysts. These protocols do not require the use of palladium and/or expensive ligands.

A general method for the formation of aryl-sulfur bonds using copper(I) catalysts

[GRAPHICS] We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % Cul and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 degreesC. Using this protocol, we have…

Synthesis of 2-arylbenzo[b]furans via copper(I)-catalyzed coupling of o-iodophenols and aryl acetylenes

[GRAPHICS] We report a copper(l)-catalyzed procedure for the synthesis of 2-arylbenzo[b]furans. This protocol can be used to synthesize a variety of 2-arylbenzo[b]furans in good to excellent yields. This method can tolerate a variety of functional…

A general method for the formation of diaryl selenides using copper(I) catalysts

We report a mild, palladium-free synthetic protocol for the cross coupling reaction of aryl iodides and phenyl selenol using 10 mol% CuI/neocuproine, NaOt-Bu or K2CO3 as base, in toluene, at 110degreesC. Using this protocol, we show that a variety of…

Copper-catalyzed synthesis of unsymmetrical triarylphosphines

Various triarylphosphines have been prepared by coupling diphenylphosphine with aryl iodides with catalytic amounts of CuI in the presence of either K2CO3 or Cs2CO3, in good yields. This method can tolerate a variety of functional groups and does not…